PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells
نویسندگان
چکیده
منابع مشابه
PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells.
OBJECTIVE Mitochondrial production of oxidants contributes to a variety of pathological conditions including the vascular complications of diabetes, neurodegenerative diseases, and cellular senescence. We postulated that a transcriptional coactivator, peroxisome proliferator activated receptor-gamma coactivator 1alpha (PGC-1alpha), a major regulator of oxidative metabolism and mitochondrial bio...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2005
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2005.01.026